Jason Mena earned a BFA in painting from the School of Visual Arts and Design in Puerto Rico, and attended Bard College Milton Avery Graduate School of the Arts Low-Residency MFA Program in Annandale-on-Hudson, before earning an MFA degree in Art Practice from the School of Visual Arts in New York City.

He has participated in exhibitions at venues including the Museum of Contemporary Art and Design in Costa Rica, Modern Art Museum in the Dominican Republic, Palais de Tokyo in Paris, Unicorn Centre for Art in Beijing, National Museum of Fine Arts in Argentina, Hessel Museum of Art in New York, Carrillo Gil Contemporary Art Museum in Mexico City, International Studio & Curatorial Program (ISCP) in New York, The Museum of Contemporary Art of Rome in Italy, Wattis Institute for Contemporary Arts in San Francisco, Patricia & Phillip Frost Art Museum in Florida, and Museum of Latin American Art in Los Angeles, among others.